Uses: Escitalopram oxalate is the active isomer of citalopram (S-citalopram), which has a highly selective ...    More ...

Uses:
Escitalopram oxalate is the active isomer of citalopram (S-citalopram), which has a highly selective inhibitory effect on the reuptake of serotonin (5-HT) and has little effect on the reuptake of norepinephrine and dopamine. It produces an antidepressant effect by increasing the concentration of 5-HT in the synaptic cleft by inhibiting 5-HT reuptake. It is mainly used for the treatment of major depressive disorder.




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Standard

                     
                                      Appearance
                                          White to light   yellow powder.
                     
                                      Identification A
                                          The IR spectrum conforms to that of Escitalopram Oxalate CRS.
                     
                                      Identification B
                                          The retention time of major peak of sample solution corresponds to   that of the standard solution, as obtained in the Assay.
                     
                                      Residue on ignition
                                          NMT 0.1%
                     
                                      Enantiomers
                                          NMT 3.0%
                     
                                      Related substances
                                          5-Dimethylaminobutyryl citalopram NMT 0.2%;
                Citalopram Related compound A NMT 0.1%;
                Citalopram Related compound B NMT 0.1%;
                Citalopram Related compound C NMT 0.1%;
                Citalopram Related compound D NMT 0.1%;
                Citalopram Related compound E NMT 0.1%;
                Any other individual unspecified impurity NMT 0.1%; Total impurities   NMT 0.5%
                     
                                      Residual solvents
                                          Toluene ≤ 0.089%; Ethanol ≤ 0.5%;Isopropanol≤0.5%
                     
                                      Water
                                          NMT 1.0%
                     
                                      Assay
                                          98.0%~102.0% calculated on the anhydrous basis.
                     
    
Less ...