Uses: Benfotiamine is a lipid-soluble derivative of thiamine, with higher bioavailability than thiamine ...    More ...

Uses:
Benfotiamine is a lipid-soluble derivative of thiamine, with higher bioavailability than thiamine itself. However, benfotiamine must be dephosphorylated by alkaline phosphatase to become a lipid-soluble precursor before it can cross cell membranes and exert its biological effects. Clinically, it is mainly used to treat diabetic complications, particularly for the treatment and prevention of diabetic retinopathy. Compared to other thiamine derivatives, this product is absorbed more rapidly and completely after oral administration. After being absorbed into the systemic circulation, benfotiamine is rapidly metabolized to thiamine without increasing the drug concentration in the brain. It also generates hippuric acid and is excreted in the urine.
                                           Items
                                          Standard
                                           
                     
                                      Appearance
                                          White   crystal or white crystalline powder
                                           
                     
                                      Identification
                                          The retention time of main peak is   accordant with that of Benfotiamine RS.
                                           
                     
                                      Loss on drying
                                          ≤1.2%
                                           
                     
                                      Clarity and color of solution
                                          Colorless to light yellow clear solution
                                           
                     
                                      Chloride
                                          ≤0.053%
                                           
                     
                                      Sulphate
                                          ≤0.011%
                                           
                     
                                      Heavy metals
                                          ≤20ppm
                                           
                     
                                      Cd
                                          ≤1ppm
                                           
                     
                                      As
                                          ≤1ppm
                                           
                     
                                      Pb
                                          ≤3ppm
                                           
                     
                                      Hg
                                          ≤0.3pp
                                           
                     
                                      Related substances:
                     
                                      Thiamine
                                          ≤0.1%
                                           
                     
                                      Benzoic acid
                                          ≤0.1%
                                           
                     
                                      Total impurities
                                          ≤1.0%
                                           
                     
                                      Assay
                                          98.0%~102.0%
                                           
                     
                                      Microbe. Test:
                     
                                      Total Plate Count
                                          ≤1000CFU/g
                                           
                     
                                      Yeast & Mold
                                          ≤100CFU/g
                                           
                     
                                      Salmonella
                                          Negative
                                           
                     
                                      E. Coli
                                          Negative
                                           
                     
                                      Staphylococcus Aureus
                                          Negative
                                           
                     
    
Less ...