Uses: Doxofylline (Doxophylline) is a phosphodiesterase inhibitor, a xanthine derivative, used to treat ...    More ...

Uses: Doxofylline (Doxophylline) is a phosphodiesterase inhibitor, a xanthine derivative, used to treat asthma.




                                           Items
                                          Standard
                     
                                      Character
                                          This product is white needle crystal or   crystalline powder
                     
                                      Melting point
                                          142℃～145℃
                     
                                      Absorption coefficient
                                          The absorbance was measured at 273 nm, and   the absorption coefficient (E1cm1% ") should be 335~356
                     
                                      Identification
                Chemical reaction
                Infrared identification
                                          Should have a positive reaction
                The infrared light absorption spectrum of   this product should be consistent with the spectrum of the control
                 
                     
                                      Acidity
                                          pH value should be 5.8~6.4
                     
                                      Clarification and color
                of solution
                                          The solution shall be clear and colorless;   If it is turbid, it shall not be thicker than No. 1 turbidity standard   solution;
                If the color is developed, it shall not be   deeper than the yellow No. 1 standard colorimetric solution.
                     
                                      Bromide
                                          No thicker (0.055%)
                     
                                      2-bromomethyl-1,3-dioxolane
                                          more than 0.0001875%
                     
                                      Related substances
                                          The ophylline shall not exceed 0.1%
                Other single impurities shall not be greater   than 0.10%
                Other impurities shall not exceed 0.4%
                     
                                      Residual solvent
                                          N. The residual amount of   N-dimethylformamide shall not
                exceed 0.088%
                Residual ethylene glycol shall not exceed   0.062%
                Residual methanol shall not exceed 0.3%
                The residual amount of ethanol shall not   exceed 0.5%
                The residual amount of dichloromethane   shall not exceed0.06%
                The residual amount of vinyl acetate shall   not exceed 0.1%
                     
                                      Loss on drying
                                          The weight loss shall not exceed
                1.0%
                     
                                      Residue on ignition
                                          Ignition residue shall not exceed
                0.1%
                     
                                      Heavy metal
                                          Heavy metals shall not
                exceed 20 ppm
                     
                                      Microorganism
                                          10³cfu/g Total aerobic bacteria   shall not exceed 2x10³ cfu/g
                The total number of molds and yeasts shall   not exceed 10²cfu/g
                Escherichia coli shall not be detected
                     
                                      Bacterial
                endotoxin
                                          It should be less than 0.05EU/mg
                     
                                      Assay
                                          Calculated as anhydrous, the content of   C11H14N4O4 should be 98.5% ～ 102.0%
                     
                                      Application
                                          Pharma Syrup
                     
                                      Solubility
                                          Soluble in Water
                     
                                      PH
                                          PH in 1% w/v solution in water is 6.5-7
                     
    
Less ...